TOKYO UNIVERCITY

The University of Tokyo , School of Engineering | Department of Bioengineering / Facility of Medicine | Center of Disease Biology and Integrative Medicine

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Sakai/Tei Group

Sakai/Tei Group Toppage

achievement

2015

Sakai*: corresponding author

  1. K. Khairulina, X. Li, K. Nishi, M. Shibayama, U. Chung, T. Sakai*, "Electrophoretic mobility of semi-flexible double-stranded DNA in defect-controlled polymer networks: mechanism investigation and role of structural parameters", Journal of Chemical Physics, in press (2015)
  2. T. Katashima, K. Urayama, U. Chung, T. Sakai*, "Probing the cross-effect of strains in non-linear elasticity of nearly regular polymer networks by pure shear deformation", Journal of Chemical Physics, 142, 174908 (2015).
  3. T. Hazama, K. Fujii, T. Sakai, M. Aoki, H. Mimura, H. Eguchi, Y. Todovov, N. Yoshimoto, M. Morita "High-performance gel electrolytes with tetra-armed polymer network for Li ion batteries", Journal of Power Sources, 286, 470-474 (2015).
  4. H. Asai, M. Haziq bin Miswan, N. Shimada, K. Nakane, T. Sakai, and N. Ogata "Preparation and characterization of a nanofiber mat consisting of Tetra-PEG prepolymers", Journal of Applied Polymer Science, 132, 41353 (2015).
  5. K. Hashimoto, K. Fujii, K. Nishi, T. Sakai, N. Yoshimoto, M. Morita, M. Shibayama "Gelation mechanism of Tetra-armed Poly(ethylene glycol) in aprotic ionic liquid containing non-volatile proton source, protic ionic liquid)", The Journal of Physical Chemistry B, 119, 4795-4801 (2015).
  6. K. Fujii, T. Makino, K. Hashimoto, T. Sakai, M. Kanakubo, M. Shibayama "Carbon dioxide separation using a high-toughness ion gel with a tetra-armed polymer network", Chemistry Letters, 44, 17-19 (2015).

Tei/Chung

2014

Sakai*: corresponding author

  1. S. Choi, IL, Liu, K. Yamamoto, M. Honnami, S. Ohba, R. Echigo, T. Sakai, K. Igawa, S. Suzuki, R. Nishimura, U. Chung, N. Sasaki, M. Mochizuki "Comparison of the long-term effects on rabbit bone defects betwen Tetrabone and b-tricalcium phosphate granules implantation" Journal of Artificial Organs, 17, 344-351 (2014).
  2. X. Li, S. Kondo, U. Chung, T. Sakai* "Degradation behavior of polymer gels caused by nonspecific cleavages of network strands" Chemistry of Materials, 26, 5352-5357
  3. K. Numata, S. Yamazaki, T. Katashima, J. Chuah, N. Naga, and T. Sakai, "Silk-Pectin Hydrogel with Superior Mechanical Properties, Biodegradability, and Biocompatibility" Macromolecular Bioscience, 14, 799-806 (2014).
  4. X. Li, K. Khairulina, U. Chung, and T. Sakai* "Electrophoretic mobility of double stranded DNA in polymer solutions and gels with tuned structures", Macromolecules, 47, 3582-3586 (2014).
  5. K. Nishi, K. Fujii, Y. Katsumoto, T. Sakai, M. Shibayama "Kinetic aspect on gelation mechanism of Tetra-PEG gel", Macromolecules, 47, 3274-3281 (2014).
  6. T. Katashima, M. Asai, K. Urayama, U. Chung, T. Sakai* "Mechanical properties of tetra-PEG gels with supercoiled network structure", The Journal of Chemical Physics, 140, 074902 (2014).
  7. H. Kamata, Y. Akagi, Y. Kariya-Kayasuga, U. Chung and T. Sakai* " "Non-swellable" Hydrogel Without Mechanical Hysteresis", Science, 343, 873-875 (2014).
  8. K. Nishi, H. Asai, K. Fujii, Y. Han, T. Kim, T. Sakai and M. Shibayama "Small-angle neutron scattering study on defect-controlled polymer networks", Macromolecules, 47, 1801-1809 (2014).
  9. S. Choi, IL. Liu, K. Yamamoto, M. Honnami, T. Sakai, S. Ohba, R. Echigo, S. Suzuki, R. Nishimura, U. Chung, N. Sasaki, M. Mochizuki "Implantation of Tetrapod-Shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model" The Journal of Veterinary Medical Science, 76, 229-235 (2014).
  10. T. Hiroi, O. Michael, T. Sakai, and M. Shibayama "Multi-scale dynamics of inhomogeneity-free polymer gels" Macromolecules, 47, 763-770 (2014).
  11. T. Sakai*, Y. Akagi, S. Kondo, and U. Chung "Experimental verification of fracture mechanism for polymer gels with controlled network structure", Soft Matter, 10, 6658-6665 (2014).
  12. K. Takagi, S. Murayama, T. Sakai, M. Asai, T. Santa, and M. Kato "A computer simulation of the networked structure of a hydrogel prepared from a tetra-armed star pre-polymer", Soft Matter, 10, 3553-3559 (2014).
  13. S. Kondo, U. Chung, and T. Sakai* Effect of prepolymer architecture on the network structure formed by AB-type crosslink-coupling" Polymer Journal, 46, 14-20 (2014).
  14. T. Ueki, Y. Takasaki, Y. Akagi, T. Ueno, T. Sakai, and R. Yoshida "Autonomous Viscosity Oscillation via Metallo-Supramolecular Terpyridine Chemistry of Branched Poly(ethylene glycol) Driven by the Belousov-Zhabotinsky Reaction" Soft Matter, 10, 1349-1355 (2014).

Tei/Chung

  1. Okada K, Fukai A, Mori D, Hosaka Y, Yano F, Chung U, Kawaguchi H, Tanaka S, Ikeda T, Saito T. Identification of SCAN domain zinc-finger gene ZNF449 as a novel factor of chondrogenesis. PLoS One 9:e115169, 2014.
  2. Kitaura Y, Hojo H, Komiyama Y, Takato T, Chung UI, Ohba S, Gli1 haploinsufficiency leads to decreased bone mass with an uncoupling of bone metabolism in adult mice. PLoS ONE 9(10):e109597, 2014.
  3. Choi S, Liu IL, Yamamoto K, Honnami M, Ohba S, Echigo R, Sakai T, Igawa K, Suzuki S, Nishimura R, Chung UI, Sasaki N, Mochizuki M. Comparison of the long-term effects on rabbit bone defects between TetraboneR and β-tricalcium phosphate granules implantation. J Artif Organ 17:344-351, 2014.
  4. Li X, Kondo S, Chung U, Sakai T. Degradation Behavior of Polymer Gels Caused by Non-specific Cleavages of Network Strands. Chem Mater 26:5352-5357, 2014.
  5. Yano F, Ohba S, Hosaka Y, Saito T, Chung U. Disease-modifying effects of TD-198946 on progressed osteoarthritis in a mouse model. Ann Rheum Dis 73:2062-4, 2014.
  6. Mori Y, Chung U, Tanaka S, Saito T. Determination of differential gene expression profiles in superficial and deeper zones of mature rat articular cartilage using RNA sequencing of laser microdissected tissue specimens. Biomed Res 35(4):263-70, 2014.
  7. Mori Y, Mori D, Chung U, Tanaka S, Heierhorst J, Buchou T, Baudier J, Kawaguchi H, Saito T. S100A1 and S100B are dispensable for endochondral ossification during skeletal development. Biomed Res 35(4):243-50, 2014.
  8. Kanke K, Masaki H, Saito T, Komiyama Y, Hojo H, Nakauchi H, Lichtler AC, Takato T, Chung UI, Ohba S. Stepwise differentiation of pluripotent stem cells into osteoblasts using four small molecules under serum-free and feeder-free condition. Stem Cell Reports 2:751-760, 2014.
  9. Ha BG1, Yonezawa T, Son MJ, Woo JT, Ohba S, Chung UI, Yagasaki K. Antidiabetic effect of nepodin, a component of Rumex roots, and its modes of action in vitro and in vivo. BioFactors 40:436-47, 2014.
  10. Mori Y, Saito T, Chang SH, Kobayashi H, Ladel CH, Guehring H, Chung U, Kawaguchi H. Identification of fibroblast growth factor-18 as a molecule to protect adult articular cartilage by gene expression profiling. J Biol Chem 289(14):10192-200, 2014.
  11. Choi S, Honnami M, Liu I, Yamamoto K, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Cranioplasty with Custom-made Artificial Bone after Resection of Multilobular Bone Tumor in a Dog. J Vet Clin 31:46-50, 2014.
  12. Kamata H,Akagi Y,Kayasuga-Kariya Y, Chung U, Sakai T. Non-swellable hydrogel without mechanical hysteresis. Science 343:873-875, 2014.
  13. Katashima T, Asai M, Urayama L, Chung U, Sakai T. Mechanical properties of Tetra-PEG gels with supercoiled network structure. J Chem Phys 140:074902, 2014.
  14. Elgali I, Igawa K, Palmquist A, Lenneras M, Xia W, Choi S, Chung U, Omar O, Thomsen P. Molecular and structural patterns of bone regeneration in surgically created defects containing bone substitutes. Biomaterials 35:3229-3242, 2014.
  15. Kondo S, Chung U, Sakai T. Effect of prepolymer architecture on the network structure formed by AB-type crosslink-coupling. Polymer J 46:14-20, 2014.
  16. Choi S, Liu I, Yamamoto K, Honnami M, Sakai T, Ohba S, Echigo R, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Implantation of Tetrapod-shaped Granular Artificial Bones or β-Tricalcium Phosphate Granules in a Canine Large Bone-Defect Model. J Vet Med Sci 76:229-235, 2014.

2013

Sakai*: corresponding author

  1. Kamata H, Chung U, Sakai T*. Shrinking kinetics of polymer gels with alternating amphiphilic/hydrophilic prepolymer unitsfdfd. Macromolecules (in press)
  2. Akagi Y, Chung U, Sakai T*. Ultimate elongation of polymer gels with controlled network structure. RSC Advances (in press)
  3. Sakai T*. Gelation mechanism and mechanical properties of Tetra-PEG gel. Reactive and Functional Polymers (in press)
  4. Asai H, Fujii K, Nishi K, Sakai T, Ohara K, Umebayashi Y, Shibayama M. Solvation Structure of Poly(ethylene glycol) in Ionic Liquids Studied by High-energy X?ray Diffraction and Molecular Dynamics Simulations. Macromolecules (in press)
  5. Akagi Y, Gong JP, U. Chung Sakai Ti*. Transition between phantom and affine network model observed in polymer network with controlled network structure. Macromolecules 46:1035-1040, 2013.
  6. Asai H, Nishi K, Hiroi T, Fujii K, Sakai T, Shibayama M. Gelation process of Tetra-PEG ion-gel investigated by time-resolved dynamic light scattering. Polymer 54:1160-1166, 2013.

Tei/Chung

  1. Li X, Khairulina K, Chung U, Sakai T. Migration behavior of rod-like dsDNA under electric field in homogeneous polymer networks.　Macromolecules 46:8665-8663, 2013.
  2. Takehara H, Nagaoka A, Noguchi J, Akagi T, Sakai T, Chung U, Kasai H, Ichiki T. Implementation of tetra-poly(ethylene glycol) hydrogel with high mechanical strength into microfluidic device technology. Biomicrofluidics 7:054109, 2013.
  3. Akagi Y, Sakurai H, Gong JP, Chung U, Sakai T. Fracture energy of polymer gels with controlled network structures. J Chem Phys 139:144905, 2013.
  4. Nakajima T, Fukuda Y, Kurokawa T, Sakai T, Chung U, Gong JP. Synthesis and Fracture Process Analysis of Double Network Hydrogels with a Well-Defined First Network. ACS Macro Letters 2:518-521, 2013.
  5. Kobayashi H, Hirata M, Saito T, Itoh S, Chung UI, Kawaguchi H.　Transcriptional induction of ADAMTS5 by an NF-κB family member RelA/p65 in chondrocytes during osteoarthritis development. J Biol Chem 288:28620-28629, 2013.
  6. Honnami M, Choi S,Liu I, Kamimura W, Taguchi T, Ichimura M, Urushizaki Y, Hojo H, Shimohata N, Ohba S, Amaya K, Koyama H, Nishimura R, Chung U, Sasaki N, Mochizuki M. Repair of rabbit segmental femoral defects by using a combination of tetrapod-shaped calcium phosphate granules and basic fibroblast growth factor-binding ion complex gel. Biomaterials 34:9056-9062, 2013.
  7. Saito T, Yano F, Mori D, Ohba S, Hojo H, Otsu M, Eto K, Nakauchi H, Tanaka S, Chung U, Kawaguchi H. Generation of Col2a1-EGFP iPS cells for monitoring chondrogenic　differentiation. PLoS ONE 8:e74137, 2013.
  8. Kayasuga-Kariya Y, Iwanaga S, Fujisawa A, Lin L, Suzuki S, Chung U, Shimohata N, Mochizuki M. Dermal cell damage induced by topical application of non-steroidal anti-inflammatory drugs is suppressed by trehalose co-lyophilization in ex vivo analysis. J Vet Med Sci 75:1619-1622,2013.
  9. Cabral H, Murakami M, Hojo H, Terada Y, Kano MR, Chung U, Nishiyama N, Kataoka K. Targeted therapy of spontaneous murine pancreatic tumors by polymeric micelles prolongs survival and prevents peritoneal metastasis. Proc Natl Acad Sci USA 110:11397-11402, 2013
  10. Yano F, Hojo H, Ohba S, Saito T, Honnami M, Mochizuki M, Takato T, Kawaguchi H, Chung U. Cell-sheet technology combined with a thienoindazole derivative small compound TD-198946 for cartilage regeneration. Biomaterials 34:5581-5587, 2013.
  11. Akagi Y, Gong JP, Chung U, Sakai T. Transition between Phantom and Affine Network Model Observed in Polymer Gels with Controlled Network Structure. Macromolecules 46:1035-1040, 2013.
  12. Maeda Y, Hojo H, Shimohata N, Choi S, Yamamoto K, Takato T, Chung U, Ohba S. Bone healing by sterilizable calcium phosphate tetrapods eluting osteogenic molecules. Biomaterials 34:5530-5537, 2013.
  13. Komiyama Y, Ohba S, Shimohata N, Nakajima K, Hojo H, Yano F, Takato T, Docheva D, Shukunami C, Hiraki Y, Chung U. Tenomodulin expression in the periodontal ligament enhances cellular adhesion. PLoS ONE 8:e60203, 2013.
  14. Hojo H, Ohba S, Taniguchi K, Shirai S, Yano F,Saito T, Ikeda T, Nakajima K, Komiyama Y, Nakagata N,Suzuki K, Mishina M, Yamada M, Konno T, Takato T,Kawaguchi H, Kambara H, Chung U. Hedgehog-Gli activators direct osteo-chondrogenic function of bone morphogenetic protein toward osteogenesis in the perichondrium. J Biol Chem 288:9924-9932, 2013.
  15. Kan A, Ikeda T, Fukai A, Nakagawa T, Nakamura K, Chung U, Kawaguchi H, Tabin CJ. SOX11 contributes to the regulation of GDF5 in joint maintenance. BMC Dev Biol 13:4, 2013.
  16. Wu S, Kasim V, Kano MR, Tanaka S, Ohba S, Miura Y, Miyata K, Liu X, Matsuhashi A, Chung U, Yang L, Kataoka K, Nishiyama N, Miyagishi M. Transcription factor YY1 contributes to tumor growth by stabilizing hypoxia factor HIF-1α in a p53-independent manner. Cancer Res 73:1787-1799, 2013.
  17. Choi S, Lee J, Igawa K, Liu I, Honnami M, Suzuki S, Nishimura R, Chung U, Sasaki N, Mochizuki M. Changes in bone regeneration by trehalose coating and basic fibroblast growth factor after implantation of tailor-made bone implants in dogs. J Vet Med Sci 75:721-726, 2013.
  18. Hosaka Y, Saito T, Sugita S, Hikata T, Kobayashi H, Fukai A, Taniguchi Y, Hirata M, Akiyama H, Chung U, Kawaguchi H. Notch signaling in chondrocytes modulates endochondral ossification and osteoarthritis development. Proc Natl Acad Sci USA 110:1875-1880, 2013.
  19. Yano F, Saito T (contributed equally),Ogata N, Yamazawa T, Iino M, Chung U, Kawaguchi H. β-catenin regulates PTH/PTHrP receptor signals and chondrocyte hypertrophy through binding to its intracellular C-terminal region. Arthritis Rheum 65:429-35, 2013.
  20. Yamauchi H, Motomura N, Chung U, Sata M, Takai D, Saito A, Ono M, Takamoto S. Growth-associated hyperphosphatemia in young recipients accelerates aortic allograft calcification in a rat model. J Thorac Cardiovasc Surg 145:522-530, 2013.
  21. Ogasawara T, Ohba S, Yano F, Kawaguchi H, Chung U, Saito T, Yonehara Y, Nakatsuka T, Mori Y, Takato T, Hoshi K. Nanog promotes osteogenic differentiation of the mouse mesenchymal cell line　C3H10T1/2 by modulating bone morphogenetic protein (BMP) signaling. J Cell Physiol 228:163-171, 2013.
  22. Yano F, Ikeda T, Saito T, Ogata N, Chikuda H, Hojo H, Kimura A, Takeda S, Nakamura K, Takato T, Kawaguchi H, Chung U. A novel disease-modifying osteoarthritis drug candidate targeting Runx1. Ann Rheum Dis 72:748-53、2013.


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